Case Study: Left Hip Core Decompression with

Stem Cell Injection in a 45 year-old male

with Avascular Necrosis (AVN) of the Hip​

A 45-year-old male with known avascular necrosis of bilateral hips presented to our office to discuss the management of the left hip. The patient previously had a right total hip replacement for avascular necrosis. He was originally diagnosed with AVN of bilateral hips five years ago. Subsequently, secondary to the collapse of the right hip he underwent a total arthroplasty.

The patients described constant pain in the left hip more so for the past year. The pain was mild in intensity and a dull ache in character. There was no radiation of pain and the pain would increase after walking for more than 10 blocks. There was no associated swelling or fever.

The patient was diagnosed with nephrotic syndrome as an adolescent. He had a long history of injectable steroids for kidney disease. The patient reported complete relief from pain after total arthroplasty on the right side.

The patient worked as an administrator for a firm and his work involved sitting for prolonged periods of time. He was a nonsmoker and a nondrinker and had no known drug allergies. He was currently taking Lisinopril and spironolactone for hypertension and kidney disease.

On physical examination, his gait was steady and coordinated. There was no evidence of exaggerated lumbar lordosis. There was no functional or structural scoliosis. The bilateral shoulders, iliac spines, patella, and the malleolus were at the same level.

On the supine examination, the skin overlying the left hip was normal with no scar or sinus tracts. There was no swelling or inguinal lymphadenopathy in the left groin. There was a well-healed surgical scar on the postero-lateral aspect of the right hip consist of previous surgery.

There was mild tenderness at the left anterior joint line. Both the anterior superior iliac spines were at the same level. There was no evidence of any leg length discrepancy. The range of motion of the left hip was normal. There were no fixed deformities in the left hip.

The examination of the lower spine, right hip, and the bilateral ankles and knees were normal. There was no distal neurological deficit and bilateral lower extremity pulses were palpable and comparable. The bulk and tone of both lower extremities were normal.

An X-ray was obtained which suggested a normal artificial joint on the right side. The left hip suggested some sclerosis with an intact spherical head of the femur. There was no crescent sign or any collapse.

Preoperative X-ray of the pelvis with both hips showing intact artificial joint on the right side and AVN of the left hip

Preoperative X-ray of the pelvis with both hips showing intact artificial joint on the right side and AVN of the left hip.

Anteroposterior view of the left hip showing pre-collapse avascular necrosis of the left hip.

Anteroposterior view of the left hip showing pre-collapse avascular necrosis of the left hip.

An MRI was obtained which was consistent with the previous diagnosis of avascular necrosis of the left hip.

The patient had Ficat & Arlet stage 2A AVN of the left hip. The patient was educated about the possibility of progression of avascular necrosis and collapse of the left hip.

After careful consideration of the patient’s condition, physical examination, and imaging studies, he was advised to undergo a left hip core decompression with stem cell injection. He was informed about the attempt to increase vascularity and reduce the intramedullary pressure of the left hip with the procedure. Risks, benefits, and potential complications were explained to the patient and his wife at length. He agreed with the plan.

DIAGNOSIS(ES): Left hip avascular necrosis.

OPERATION: Aspiration of stem cells from the left iliac crest and concentrating them using the harvest system and core decompression with an injection of stem cells into the left hip.

ESTIMATED BLOOD LOSS: Minimal.

DESCRIPTION OF PROCEDURE: The patient was brought to the operating room after obtaining informed consent and signing the correct surgical site. The risks, benefits, and alternatives were extensively discussed with the patient prior to the procedure.

The patient was brought to the operating room, and the patient was anesthetized by the anesthesiologist. The patient was then definitively positioned on the fracture table and fluoroscopy was performed. The left hip was then draped and prepped along with the left iliac crest in the usual sterile manner.

Jamshidi needle was inserted into the left iliac crest and about 180 ml of fluid was aspirated. The aspirate was processed using the harvest system. The two guidewires were then placed into the left hip under fluoroscopic control in a percutaneous manner. Core decompression was performed at the location of the avascular necrosis.

Anteroposterior view of the left hip showing pre-collapse avascular necrosis of the left hip Anteroposterior view of the left hip showing pre-collapse avascular necrosis of the left hip - img 2

Anteroposterior view of the left hip showing pre-collapse avascular necrosis of the left hip.

Core Decompression at the site of avascular necrosis

Core Decompression at the site of avascular necrosis.

Concentrated stem cells were then injected into the defect after removal of the guidewires. The injection was performed after tilting the table towards the other side. Cutaneous tissues were closed. The skin was closed using Monocryl. Sterile dressing was then applied over the wound, and the patient was then transferred to the postoperative care unit in stable condition.

Postoperative image after core decompression and injection of stem cell harvest

Postoperative image after core decompression and injection of stem cell harvest.

The patient’s vitals remained stable after the procedure. There was no distal neurological deficit after the procedure. He was allowed to bear weight as tolerated with support after the procedure. The post-operative pain was managed with pain medications.

The patient followed up after three months of post suture removal. He was walking without support and had a full range of motion. He follows up regularly for surveillance of the progression of avascular necrosis.

Disclaimer – Patient’s name, age, sex, dates, events have been changed or modified to protect patient privacy.

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00:52 30 May 23
Excellent and skilled orthopedic practice specializing in joint replacements. Dr Karkare was trained at the Hospital for Special Surgery and has excellent results, as do his associates!! Would gladly refer family members to the practice!!
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00:24 30 May 23
I had such a wonderful experience with Complete Orthopedics in Stony Brook. Not only did Dr. Kuo fix my broken wrist with such kindness and care, but the office staff, including Billing, Reception and the X-Ray Technician, was always so helpful, going out of their way to ensure that each patient felt welcome, answering any questions with a smile, and ensuring any issues with insurance/billing were handled with the utmost professionalism. I highly recommend their practice!
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19:49 10 May 23
I'm very happy St. Catherine's sent me to this office for treatment after I broke my collar bone! Unfortunately the break was too severe to repair on its own and I had to have it rebuilt a week after the injury. Dr. Vaksha did a great job fixing it. I'm three months out, and I have full use of the arm and shoulder. The whole office staff is very professional, accommodating, and welcoming. I hope to not need orthopedic services again, but Dr. Vaksha will be my number one choice if I or anyone in family suffers such am injury.
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21:23 25 Feb 23
Dr Vaksha was so kind and helpful. He took extra time with us and explained things so thoroughly. Highly recommend. Office very clean.
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20:20 19 Feb 23
Dr Vaksha, is a great doctor very professional knows what he talking about. Treat patient with upmost respect. Thank You
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16:46 19 Jan 23
Dr. Karkare is an amazing doctor, very caring and attentive, the girl at the front desk is very kind and helpful. .elizabeth .thank you so much .
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21:32 26 Oct 22
Been going to this place before my accident and after I had my knee surgery. So happy how I been treated and how well I am getting. Thank you all and specially Dr. VAKSHA for everything and getting back on track.
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21:28 23 May 22
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23:31 19 May 22
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19:54 16 May 22
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23:17 12 May 22
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19:54 05 May 22
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00:46 03 May 22
I have seen Dr. Kuo two times already and he's awesome along with his staff. Very friendly office and I'm glad to be a patient here.
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20:01 28 Apr 22
Amazing team!! Very caring, profesional, and friendly!! Dr. Kevin Kuo, you are the best, very passionate, caring, and helping thank you for getting me better and being so kind to me! Elizabeth you the best thank you for you help always and you big smile and positive actitud❤️🙏🏼
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19:01 22 Apr 22
The staff is truly exceptional, they make you feel comfortable and welcomed. The doctors are amazing,always professional, compassionate and great listeners.
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03:25 09 Apr 22
What a great place! The place is clean and organized.The staff is wonderful. Setting up physical therapy is right there as well.I'm so glad I found this place.
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22:45 05 Apr 22
This was my 1st time breaking something in my 27 years on this planet. I was recommended here by a friend Dr. Vashka helped me from day 1 and still continues to check in on me and my healing ankle. Would highly recommend
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16:06 01 Apr 22
Brand new office, same great doctors! Rooms are clean, plenty of parking, physical therapy attached, Dr. Karkare and his staff are awesome. Thank you!
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02:49 24 Mar 22
Dr.VAksha is the best, I love the way he treats me as his patient, he is caring,understanding and very attentive to my needs
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14:53 03 Mar 22
Great staff. Dr. Vaksha is awesome and takes the time to listen to his patients. He is very compassionate. I would highly recommend this office.
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01:24 23 Feb 22
After suffering from a severe ankle injury Dr. V was able to help me heal and return back to work completely to a job where I stand for 12 hours a day. The office is very clean and I appreciated the reminders of my appointments via phone call and through text. The patient portal made it easy for me to access all my documents including work notes. The office staff is wonderful and Rebecca was able to schedule me with a busy schedule and awesome at answering all of my questions including referring me to a great physical therapy office. I highly recommend this office to anyone who’s looking for knowledgeable and kind orthopedic office.
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21:31 28 Jan 21
The staff here are great, I was seen at the time of my appointment and was well taken care of!
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18:14 07 Jan 21
They are an excellent practice. The front and back office people are amazing and so helpful. Rebecca is such a kind and understanding person. I had an issue with paperwork and she cleared it right up. Dr. Karkare is very knowledgeable, helpful, and caring.
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19:31 18 Nov 20
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18:17 17 Nov 20
Great experience, the Doctor is nice but the staff is incredible. I worked with Linda, who was profession and assisted me beyond what any person has done at other practices. Complete Ortho should be complimented for having such a person on their staff.I highly recommend this place!!!
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17:26 17 Nov 20
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I was rear ended in an auto accident , Dr Vashka was recommended by a friend of mine .I was experiencing Back , neck , and shoulder pain . After a thorough examination and given exercises to do at home , I am feeling much better , and I ended up avoiding surgery . The staff at Complete Ortho is extremely attentive and show great care when making an appointment and are very friendly and i never waited more than 5 minutes for my appointment . So I would strongly recommend Complete Orthopedics for any aches and pains that one might be experiencing.....
Bill Becht
04:44 17 Nov 20
It was the afternoon of Friday Sept. 24. We were in Pt. Jefferson and my wife, Mary Ann, broke her hip. We went to Mather Hospital and it was determined that she would have to have an operation to have it repaired. This would be her third time under the knife in the past year. It just so happened that we were very fortunate enough to have Dr. Karkare, who was on standby, perform the surgery. He put in a rod and two screws in her hip. She spent a few days in the hospital and then went to Gurwin rehabilitee for another few weeks.It has now been almost six weeks and we both worked the election the other day. If it wasn’t for Dr. Karkare’s expertise she never would have been able to work. She is able to walk with a walker and is doing physical therapy three times a week.We can not thank the doctor enough for the compassion and dedication that he puts into his work. It allows Mary Ann do the things that she likes to do, even on a limited basis for a while. I know that with her will, perseverance and the great work that the surgeon performed she will be back on her feet in no time.Sincerely:John V. PlumpEast Northport, NY 11731
Jack Harris
14:36 06 Nov 20
In the year of 2018 I was referred to Dr. Karkare because I was experiencing severe knee joint pain. After exhausting physical therapy and trying to labor through the pain, I had to make a quality of life decision. Total knee replacement was the only viable option. Dr. Karkare made my decision easy as he walked me through the whole process from surgery to recovery.On 12/13/19 ( Friday the 13th) I enter Lenox Hill Hospital in great hands. From the time I entered Dr. Karkare’s office for the first time until now, his staff has been amazing. Andrea the medical coordinator walked me through all the paper work and necessary preparations for the surgery. Courtesy and kind would be an understatement. Dr. Karkare went over and beyond from the wellness checks and phone calls all to assure me that I was important to him. This was the right decision no pain and no limp. Complete Orthopedics should be your choice!
Kenneth Randolph
22:18 25 Sep 20
Dr. Vadshka has a great bedside manner. He really takes his time and explains treatment options.
T Lee
12:33 09 Sep 20
I suffered with pain in both knees for years. My orthopedic doctor kept recommending knee replacement . I fought it for years, as I was just afraid. When I had no choice and could barely walk , it was recommended I see Dr. Karkare. We set up a consultation and my wife and I left his office feeling totally confident and comfortable with moving ahead with the surgery. He explained everything to us, and the office staff set everything up for us and made the process easy. So about one month after our initial meeting I had the first knee done. I was up walking mere hours after the surgery, and on the workout machines the next morning. I went home two days after the surgery, and yes walked my daughter down the aisle at her wedding only one week after the surgery without even a cane! Three months later I had the other knee done and went home the very next day. Dr. Karkare put my fears to rest . I would highly recommend him. His expertise gave me my life back. Thank you Dr. Karkare.SincerelyVito Congro
Ethel Congo
23:58 12 Aug 20
Dr Rhodin really cares for his patients. When I see him he makes sure to review my progress in detail.
Micki Cahill
15:03 08 Feb 20
My mom had a total hip replacement by dr karkare. He is the BEST orthopedic doctor.Her incision is almost invisable.She is going back for her other hip next week. The office staff is the best, love Andrea.You wont find a better doctor.
Ryan Brigandi
21:06 13 Jul 18
There is no better Orthopedic doctor you will find. Broke my ankle three places on a Saturday. Called Dr. Karkare. He had is team ready at the hospital and operated on me within 6 hours after my injury. Now After 3 months of great care by him and his staff, I am walking to normalcy.
Spacecom Tel
04:13 23 Mar 18
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My name is Dr. Suhirad Khokhar, and am an orthopaedic surgeon. I completed my MBBS (Bachelor of Medicine & Bachelor of Surgery) at Govt. Medical College, Patiala, India.

I specialize in musculoskeletal disorders and their management, and have personally approved of and written this content.

My profile page has all of my educational information, work experience, and all the pages on this site that I've contributed to.